![]() ![]() Herbivores exhibit specializations at the intestinal level that facilitate the bacterial fermentation. As for the ultrastructural features in the "TR" mucosa, the secondary effect cannot be excluded at the present. Previous work7,8 further suggests that the mucin changes may be primary, reflecting a cellular response to unknown stimuli (i.e., carcinogens) rather than a local secondary effect of tumor growth. It is suggested that mucin and ultrastructural changes described in the "TR" zone may indicate a failure in the normal process of cell differentiation along the crypt. C) An elaborated and enlarged Golgi zone showing increased secretory activity. B) Appearance of electron-dense bodies 0.15-0.3mum in in diameter and membrane limited. Goblet cells are increased in number and size. Mature absorptive cells are fewer and bear an inverse relationship to intermediate cells. At the ultrastructural level, the "TR" mucosa is characterized by the following changes which may precede the histochemical variations: A) alteration in the relative proportions of the different cell types, along the crypt, with a persistence of immature and intermediate cells at higher levels of the crypt than in the control. shows an increase in sialomucins as compared with the "N" and control mucosae, where sulphomucins normally predominate. These were compared with similar studies on the mucosa from control individuals. A parallel study by electron microscopy and mucin histochemistry was made on fragments from "transitional" (TR) mucosa (adjacent to carcinoma) and "normal" (N) mucosa (remote from the tumor). The material was taken from surgical specimens of large intestine resected for carcinoma. Small bowel transmit time in RY was slower than that in JI group and C group (P<0.01).Ĭhanges of body weight and intestinal motility in JI group are less influenced than in RY group. The difference was more significant at six months postoperative. However, the body weight of RY group decreased compared to preoperative (255.1+/-11.3 g vs 295.0+/-12.0 g, P<0.01). Four months after the operation, the body weight in the JI group increased compared to the preoperative level (345.2+/-15.7 g vs 299.5+/-8.3 g, P<0.01). One month after operation, the body weight of rats among JI and RY were almost identical (274.6+/-9.5 vs 270.4+/-10.6, P>0.05), but were significantly lighter than those of JT and L group. The rats were executed by CO(2) inhalation 30 minutes later and the intestinal transmit was determined as the distance between the site of esophageojejunal anastomosis and the most distal site of small intestine colored with blue. To evaluate intestinal transit, the animals were given 0.1 ml Evans Blue solution through an orogastric tube. ![]() ![]() To compare the effects of Roux-en-Y and jejunum interposition reconstruction procedures after total gastrectomy on intestinal motility.įifty male Sprague-Dawley rats were randomly divided into 5 groups: the control group (C), the laparotomy group (L), the jejunal transection group (JT) where the jejunum was transected 10 cm distal from the Treitz ligament and anastomosed, the Roux-en-Y group (RY) and the jejunal interposition group (JI) after total gastrectomy. ![]()
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